Category Archives: Obesity

Obesity-associated Liver cancer

Obesity has been on the rise in developed countries over the past few decades. In spite of the fact that weight has long been connected to diabetes and cardiovascular disease, it is additionally progressively being recognized as a leading hazard in numerous forms of cancer. For illustration, one recent study found that obesity-associated inflammation contributes to hepatocellular carcinoma, a sort of liver cancer and the third leading cause of cancer deaths in people around the world. Obesity drives a change of the gut microbiome, leading to the discharge of metabolites associated with the advancement of liver cancer.

Obesity spurs changes within the intestine microbiome that can lead to the production of DNA-damaging metabolites. Circulation of these metabolites through the intestine and liver initiate inflammatory and tumor-promoting components that produce more susceptible to liver cancer. Changes to the trillions of microbes that are found in the intestine in reaction to obesity can contribute to the formation of damaging microbial metabolites.

To explore how obesity might cause cancer, researchers turned to a mouse strain expressing a luminescent marker for a quality that actuates a condition called the senescent-associated secretory phenotype (SASP). Though senescence, the cessation of cell division that accompanies old age, has been appealed to suppress tumor formation, later prove shows that beneath certain conditions, senescent liver cells produce pro-inflammatory components that advance tumor growth. Cells in this senescent but pro-inflammatory state are showing SASP.

The researchers to begin with looked for a distinction in cancer development between obese mice encouraged high-fat count calories and incline mice encouraged a typical count calorie. Unable to observe a critical distinction, the researchers suspected that obesity-linked cancer may require an oncogenic stimulus. Beyond any doubt enough, when exposed to a chemical carcinogen, all of the obese mice developed liver cancer, while as it were 5 percent of the lean mice did. The obese mice too had higher levels of the SASP luminescent marker within the hepatic stellate cells the essential cell sort involved in the formation of scar tissue taking after liver damage suggesting that obesity invigorates the condition.

To explore how obesity might cause SASP, the researchers looked to recent prove that obesity is related to large-scale changes to the trillions of microscopic organisms within the gut that can produce harming inflammatory metabolites. Thinking that proliferating organisms within the gastrointestinal tracts of the obese mice can be triggering SASP, the researchers treated the mice with vancomycin or a cocktail of four antimicrobials to kill off most of the microbes. The treated mice appeared a noteworthy reduction in liver cancer, suggesting that certain intestine bacteria were undoubted to blame for the spike in cancer frequency. The discoveries involve hepatic stellate cells as a vital transducer of the signals that arise from the microbiome in changing the microenvironment to favor the rise of cancer

The researchers were moreover able to pinpoint a specific intestine microbes metabolite the known carcinogen deoxycholic acid (DCA) as the trigger for SASP. Repressing the generation of DCA suppressed liver cancer in obese mice, while antibiotic-treated mice given a high-fat diet counting DCA experienced a surge in liver cancer. So distant, They have been able to illustrate that the gene expression of incendiary components related with SASP can be actuated in human hepatic stellate cells in vitro. In addition, investigate by other bunches has found that human patients with non-alcoholic fatty liver infection, a hazard factor for liver cancer, have been appeared to show signs of SASP in hepatic stellate cells.

Apple: The Original Super fruit

Apples keep the doctor away since they are one of nature’s best superfoods. There’s so much nourishment in apple fiber, antioxidants, vitamin C, phytonutrients and more! Apples are one of the most advantageous foods an individual can eat. They are high in fiber and vitamin C, and they are too low in calories, have only a follow of sodium, and no fat or cholesterol. Apples are high in polyphenols, which work as cancer prevention agents. These polyphenols are found in both the skin of the apples as well as within the meat, so to get the greatest amount of benefits, eat the skin of the apple. All of these benefits cruel that apples may moderate the impacts of asthma and Alzheimer’s infection, whereas helping with weight administration, bone wellbeing, pulmonary work, and gastrointestinal protection. Frequently called a “miracle food” and “nutritional powerhouse,” an apple a day truly may keep the doctor away.

Apple

Health benefits

  • Lower “bad” cholesterol: Procyanidins in apples (a type of flavonoid) have high antioxidant action and lower low-density lipids (LDL or “bad” cholesterol).
  • Help your heart: By decreasing cholesterol, the high polyphenol content from frequent apple consumption could also lower cardiovascular disease risk.
  • Stimulate healthy digestion: Apple polyphenols and fiber may also strengthen the microbiome in the gut.
  • Safeguard your mind: The high levels of antioxidants in apples protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s and keep up brain performance.

Apples are loaded with vitamin C. Almost half of an apple’s vitamin C substance is fair beneath the skin, so it’s a great thought to eat apples with their skins. Apples contain insoluble fiber, which gives bulk within the intestinal tract. The bulk holds water that cleanses and moves nourishment rapidly through the digestive system. Regular intake of apples has been appeared to have cardiovascular benefits. This is often due to two properties of apples: the fiber that they contain and the polyphenols that are found in tall amounts. In expansion to digestion-aiding insoluble fiber, apples have solvent fiber, such as pectin. This supplement makes a difference anticipate cholesterol from building up within the lining of blood vessels, which in turn makes a difference avoid atherosclerosis and heart disease. When it comes to polyphenols and antioxidants, they work within the cell lining to diminish oxidation coming about in bringing down the chance of cardiovascular disease. Those who eat more apples have a lower hazard of stroke. Researchers credited the results to quercetin, an antioxidant in apples. There are respiratory benefits to eating apples, as well. Apples’ antioxidant benefits can offer assistance lower the chance of asthma. Eating entire apples gives filling, health-promoting fiber (up to 5 grams per apple!) and plant-based cancer prevention agents, who offer assistance support resistant work. Most are stacked sources of actually happening sugar (“apple juice concentrate”) furthermore water, making it higher in calories without keeping you fulfilled. Additionally, the preparing that removes pulp and clarifies the juice too diminishes the sum of cancer prevention agents.

Apples and cancer

The antioxidant substance of apple positions among the highest for natural products and inquire about appears that cancer prevention agents offer assistance avoid cancer. Lung cancer chance can particularly be brought down through apples’ cancer prevention agents, concurring to Flores. Individuals who routinely eat apples, onions and white grapefruit cut their lung cancer chance in half.

Health risks

Furthermore, apples are acidic, and the juice may harm tooth finish. Numerous individuals eat apples gradually, which increments the probability that acids will harm tooth finish. Snacking on acidic foods all through the day is the foremost harming, whereas eating them at supper times is much more secure. An apple a day is sweet, but taking all day to eat the apple can harm teeth. Dentists prescribe cutting up apples and chewing them with the back teeth. They moreover prescribe flushing the mouth with water to assist wash absent the corrosive and sugars.

Want to shed Weight? Eat Ghee..!!

Desi ghee, the one made from cow’s milk, is packed with essential nutrients that are so useful for the mind as well as body. If anyone is trying to slim down or get rid of the obstinate belly fat, you should include ghee in your daily diet and fire up their weight loss journey.

Do agree that ghee, the Indian version of clarified butter or Desi Ghee, is unhealthy and fattening? Though many people consider that ghee causes weight gain, health experts say the opposite. Actually, homemade and pure ghee or simply desi ghee, especially the one obtained from cow’s milk is packed with crucial nutrients that are so worthy for both mind and the body. Even modern science now agrees about the Ayurveda’s claims of cooking benefits and health of ghee.

Ghee is a vulnerable source of healthy fatty acids and fat-soluble vitamins, which helps in weight loss. Ghee is also enriched with essential amino acids, which assist in assembling the fat and making the fat cells to deflate in size which can later on be burnt for energy. Ghee is also a good source of memory-boosting omega-3-fatty acid docosahexaenoic acid (DHA) as well as omega-6 fatty acid interconnected linolenic acid (CLA). Studies have shown that omega-6 fatty acids helps to attain lean body mass and reduce fat mass, which in turn, helps in weight loss and weight management. Similarly, omega-3s may also help in losing inches and shedding body fat.

“The butyric acid along with combination with vitamins A, D, E, and K found in ghee aids in boosting immunity, keeps your hair and skin healthy, promotes gut health, lubricates joints and strengthens our bones,” says Loveneet Batra, nutritionist, Fortis Lafemme, New Delhi.

Apart from helping you lose weight, ghee also improves digestion and prevents inflammation. It can also protect us from cancer when consumed daily. It revitalize every cell functioning and helps looks after the overall health.

But remember over-consumption of ghee can cause some problems, keep in mind that it has high amount of saturated fats. It is advised to take not more than two to three teaspoons of ghee to lose weight and make sure you eat a healthy diet and indulge in daily exercises to burn belly fat and lose weight.

Eating Disorder

EatingIf you are obsessed over food, body weight and shape, there might be a chance of having Eating Disorder. People often think that eating disorders are a lifestyle choice. But they are actually serious and often fatal mental illness and are an important cause of physical and psychosocial morbidity in an individual. According to various studies on eating disorders, the results found that the frequency of occurrence is much less in men as compared to adolescent girls and young adult women and a large proportion of eating disorder patients were exercising excessively during an acute phase of the disorder.

Types of Eating Disorders

They are divided into three diagnostic categories: Anorexia Nervosa, Bulimia Nervosa, and Binge-eating disorder.

  • Anorexia Nervosa, characterized by inadequate intake of food. In this condition, people may have unrealistic perception of overweight, even when they are dangerously underweight and thus, they severely restrict the amount of food they eat, and eat very small quantities of only certain foods. It can lead to damaging health effects, such as loss of bones and skin integrity, increases the risk of heart attacks and related heart problems, brain damage, multi-organ failure, and infertility. The mortality rate is highest in this disease as compared to other mental disorders, either due to complications associated with starvation or the patient commits suicide.
  • Bulimia Nervosa, characterized by an excessive intake of food followed by compensatory behaviors for the overeating such as forced vomiting, excessive use of laxatives or diuretics, fasting, excessive exercise, or a combination of these behaviors. Although people usually maintain their relatively normal and healthy weight, but the irregular food behaviors can have injuring effects, such as chronically inflamed and sore throat, severe gastrointestinal problems, severe dehydration, and various heart difficulties resulting from an electrolyte imbalance.
  • Atypical eating disorders: There are many other types of eating disorders including Binge-eating Disorder (lack of control on eating), other specified feeding or eating disorder (OSFED), Diabulimia, etc.

Cause of Eating Disorder

Although the cause of eating disorders is not clear but it seems like combination of biological, psychological, and environmental factors plays an important role in the development of these illnesses.

  • A high proportion of individuals diagnosed with body dysmorphic disorder (way the person sees themselves) also had some type of eating disorder.
  • Biological conditions such as hormone irregularities and nutrition deficiencies can also lead to eating disorders.
  • The environmental factors include Dysfunctional family dynamic, aesthetically oriented sports, Professions and careers, childhood traumas and other stressful transitions.

Treatment for an Eating Disorder

People often ignore such conditions which then results in severe adverse effects. Because of severity and complexities of these conditions, it has become necessary to establish a comprehensive and professional treatment. Addressed with medical doctors, nutritionists, and therapists for complete care, the treatment includes:

  • Individual, group, and/or family psychotherapy
  • Medical care and monitoring
  • Nutritional counselling
  • Medications

Genetic regulation of metabolomic biomarkers: Paths to cardiovascular diseases and type 2 diabetes

Diabetic

The research has revealed eleven new genetic regions associated with the blood levels of the metabolites, including new loci affecting well-established risk markers for cardiovascular disease and potential biomarkers for type 2 diabetes.

In a study to the genetic variance of human metabolism, specialists have identified thirty one regions of the genome that were related with levels of circulating metabolites, i.e., small molecules that take part in different chemical reactions of human body. Many of the studied metabolites are biomarkers for cardiovascular disease or related disorders, accordingly the loci uncovered may provide valuable insight into the biological processes leading to common diseases.

Lab tests used in the clinic typically monitor one or few circulating metabolites. The researchers used a high throughput method called nuclear magnetic resonance that can measure more than hundred different metabolites in one assay. This provides a considerably more in-depth picture of circulating metabolic compounds.

The group assayed 117 detailed metabolic markers, including amino acids, lipids and lipoprotein subclasses, and conducted the largest genome-wide association analysis of this type, in terms of study sample size of 8330 individuals and 7.7 million genomic markers studied. They revealed, in total, 31 genetic regions related with the blood levels of the metabolites.

Among the discoveries were two new loci influencing serum cholesterol subclass measures, well-established risk markers for cardiovascular disease, and five new loci affecting levels of amino acids recently discovered to be potential biomarkers for type 2 diabetes. The found variants have significant effects on the metabolite levels, the effect sizes being in general considerably larger than the known common variants for complex disease have.

Additionally, using twin pair samples, the scientists indicated that the metabolite levels show a high degree of heritability. This result suggests that the studied metabolites are describing better the underlying biology than the routinely used lab tests. In this way, the examination provides further support for the use of detailed data on multitude of metabolites in genetic studies to provide novel biological insights and to help in elucidating the processes leading to common diseases.

Dietary Fat Linked To Pancreatic Cancer

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A high-fat diet may advance the development of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK), a digestive hormone. In addition, blocking CCK may help anticipate the spread of pancreatic tumors to other regions of the body (metastases). CCK is released by the small digestive tract and is related to obesity. Dietary fat triggers the secretion of CCK; those who follow a diet high in immersed fats often have high levels of CCK. Past research has appeared that obesity and high-fat diets both together and independently increase the chance of pancreatic cancer. CCK too controls recovery that takes place after partial surgical removal of the pancreas. Pancreatic growth and regeneration occur through the interaction of CCK with CCK receptors, proteins that tie to CCK to produce a physiological reaction.

Identification of pancreatic cancer risk factors is of great significance since few people survive long after the determination. Pancreatic cancer is the 4th driving cause of cancer passing within the world. Impact of high unsaturated fat utilization epidemiologic literature on dietary fat intake and pancreatic cancer risk is conflicting, with a few studies finding an expanded chance of pancreatic cancer with higher total fat or saturated fat utilization and others appearing an expanded or reduced hazard of pancreatic cancer with higher particular saturated and monounsaturated fatty acid intakes. Other studies show no association with pancreatic cancer risk some studies have moreover appeared a positive affiliation for animal fat intake generally and particularly for fat from red meat and dairy. Dietary fat intake is especially challenging to study in relation to pancreatic cancer given the expanded undetectable stage of tumorigenesis and the dietary changes that can occur during this pre-diagnostic, but progressively symptomatic period. Studies that account for changes in dietary practices in the years prior to diagnosis are required to address the problem of reverse causation. The affiliation between fat intake and pancreatic cancer risk in a large, prospective cohort of men and women.

Men and women who consumed high amounts of total fats have 53% and 23% higher relative rates of pancreatic cancer, respectively, compared with men and women who had the least fat consumption. Excess body fat is one of the strongest components increasing risk for pancreatic cancer. Low-fat diet decreased the chance of pancreatic cancer among a targeted bunch of postmenopausal, obese women. Low-fat diet is especially viable in reducing pancreatic cancer hazard in overweight and obese postmenopausal women.

Does Vegetarians Suffer from Obesity?

obesity-young-adult2Vegetarian diets may play a significant role in promoting health and in the prevention of obesity. Vegetarianism encompasses a range of eating patterns that are diets which leave out all animal products as well as meat to diets that include milk, eggs, fishes and milk products. A previous study has indicated that BMI increases when a wider range of animal products like meat or eggs are eaten. Specifically, the European Prospective Investigation found that BMI was highest in meat eaters, lowest in vegans, and was found to at intermediate level in fish eaters. The positive effects of vegetarian against overweight is may be due to restraining major food groups, shifting of calories toward food groups that are more fuller effect.

Research shows that cutting down on meat and switching to a diet rich in fruit and vegetables lowers the risk of obesity. People who prefer a diet heavy in meat, eggs, dairy and animal fats  are obese than the people who eat around double the amount of fruit and vegetables, grains, pulses, olive oil and who enjoy potatoes.

Professor Maira Bes-Rastrollo, from the University of Navarra in Spain, recently presented the study at the European Congress on Obesity in Porto. She claimed that plant-based foods contains more fibre and helped people feel fuller for longer thus preventing obesity.

Doubtlessly, plant based diets, especially vegans, have lower BMIs in general. Studies have proven that, on average, meat eaters are nine times the obesity rate of vegans. Vegans are 10-20 pounds less on average.

In one of the case study, it was found that the ubiquity of overweight was 40% among omnivores, 29% among both semivegetarians and vegans, and 25% among lactovegetarians.

Weight loss success is achieved only when the food choices reflect an overall decrease in calories taken and a corresponding increase in calories spent. These choices are referred to food and drink as well as the calorie expenditure.  But the good news is that turning vegetarian in a healthful way can help an individual to achieve this goal and keep obesity off long-term.

Fat Burning Foods

16If you feel like making a smart move to control obesity or lose weight but can’t see the scale prove you right, it may be because your diet contains some devious foods that lead to bloating, water retention as well as higher calorie intake.

Boosting the metabolic rate helps in losing body fat. However, most “fat-burning” supplements on the market are either ineffective, or unsafe or both. Fortunately, several natural foods and beverages have been shown to increase metabolism and promote fat loss.

“People will go crazy and cut out whole food groups” says Nutritionist Jess Cording, R.D, “or they are really intense with exercise without refueling appropriately.  But it’s really important build in time and gives your body adequate calories and nutrients”.

The fat burning foods starts slimming your waistline. They build muscle, promote fat burning or simply use energy in order to digest them.

Certain foods have a very high thermogenic effect, so you invest calories as you chew. Other foods contain nutrients and compounds that speeds up the metabolic rate.

Some of the fat burning foods include almonds and other nuts with skins intact. They help in building muscle and reduce cravings. Eggs are known to build muscle and burn fat. Lean Meats strengthen immune system. Berries improve satiety and prevent cravings. Oranges and red vegetables provide health-boosting beta-carotene, fibre as well as phytochemicals. Peanut Butter boosts testosterone, builds muscle as well as burns fat. Fatty Fish such as tuna, salmon and mackerel trigger the feeling of fullness and aids in fat burning. Grapefruit lowers insulin, regulates blood sugar and metabolism. Green Tea fires up fat burners. Chilli Peppers spike your metabolism. Spinach and Green Vegetables improve recovery for better muscle building and fight free radicals. Whole-grains and rice prevent the body from storing fat. Beans and legumes help burn fat, build muscle regulate digestion. Whey builds muscle and burns fat.

Despite what some supplement processors may suggest, there isn’t anything like a safe “magic pill” that can help you burn hundreds of extra calories per day.

However, a number of foods and beverages may meanly increase your metabolic rate, in addition to providing other health benefits.

Considering several of them in your daily diet will definitely lead to fat loss and better overall health.

Are pineapples healthy for Diabetic or Obese person?

obesity diet 2018A healthy diet should include portion of various fruits. Fruits such as pineapples are a healthy choice for people with diabetes as well as obesity. Pineapple is one such fruit that is a powerhouse of nutrition as well as tastes great.

It is packed with thiamine also known as Vitamin B1, Vitamin C, and rich in iron. It also contains an enzyme called bromelain which helps in digestion and its juice is thought to be a diuretic. It has anti-inflammatory properties and is also an anti-oxidant. Since it is rich manganese, it also boosts bone health. Pineapple also can contain carbohydrates that affect your blood sugar as well as body’s metabolism.

As a source of carbohydrate, mostly sugar, it’s not likely that pineapple could lower blood sugar. However, as a fruit that digests more quickly than others, some may experience a low blood sugar effect, especially if they have diabetes.

However, Harvard researchers reported that consuming three servings of whole fruit per week, particularly blueberries, raisins,  grapes and apples as well as pears, reduces the risk of developing type 2 diabetes by almost 26 per cent. Additionally, fruits’ glycaemic index (GI), a rating which indicates how quickly food can raise blood sugar, did not play a significant role in determining individual fruits’ effects on diabetes risk. “High” as well as “Moderate” glycaemic index of fruits that include pineapple and many dried fruits as well as dried fruits were just as notable as low glycaemic index choices.

The belief that diabetics should avoid certain fruits is unproven.

The present study was conducted to assess anti-obesity effects of raw pineapple juice in high fat diet (HFD)-induced fatness.

Pineapple has progressed toward becoming a recommended fruit in obesity as well as dyslipidaemia treatment as it contains a high amount of bromelain, which has a role in lipolysis and diminishing the severity of cardiovascular syndromes.

Pineapple juice, therefore, may possibly be used in anti-obesity category where it decreases lipogenesis (the process through which fat is formed) and increased lipolysis (the process by which fats are broken down).

Let’s get to know about some of the interesting facts of bariatric surgery

Myths and reality!!!

Due to the changing lifestyle and tremendous increase in the obesity related problem bariatric surgery has become one of the emerging fields.

Myth 1: Bariatric surgery is only for the morbidly obese

Reality: Obesity is only the primary category that makes the situations for the victims to undergo surgery but, the overweight patients are also subjected to bariatric surgery when they are supposed to have the problems like diabetes, hypertension, sleep apnea, arthritis and others.6

Myth 2: Liposuction and Bariatric surgery are same

Reality: Liposuction is cosmetic surgical procedure that is involved in shaping the body whereas the bariatric surgery is the metabolic surgery that works on the general mechanism of the body to gain control over the weight.

Myth 3: Vitamin & Mineral deficiencies are caused by the bariatric surgery.

Reality: Bariatric nutritionists generally gives the diet chart through which the vitamin and mineral deficiencies supposed to occur can be balanced.

Myth 4: After Bariatric surgery you cannot eat any foods that tastes to be good.

Reality: Patients who underwent gastric bypass should avoid very sweet foods because it can cause some side effects but most of the victims eat their favorite foods and enjoy after they recover from the surgery.7

Myth 5: Post-surgery diet before you have the operation

Reality: Post surgery diet before the operation is essential since we can have some natural weight reduction and reduces the risk of complication at the later stages of operation.