Category Archives: Heart Regeneration

Pediatric cardiology

There is a number of heart conditions that can affect children. Few children have structural differences by birth others involve the electrical system that controls the heartbeat. Pediatric cardiologists mainly treat, diagnose and manage the problems in the child.  Pediatric heart problems in children include congenital heart disease and Arrhythmias. Congenital heart disease refers to heart structural variation by birth in the child which include holes between chambers of the heart, abnormal blood vessels and valve problems. Arrhythmiasis know as abnormal heart rhythms caused by the system that controls the heartbeat electrically. Pediatric cardiologists will treat pulmonary hypertension and systemic hypertension. Systemic hypertension means high blood pressure in the body. But in few regions, pulmonary hypertension is treated by pediatric pulmonologists and systemic hypertension is treated by pediatric nephrologists.

edhgjnIn Food industries generally, Pediatric cardiologists work closely with primary care pediatricians to provide coordinated and comprehensive care. Heart Problems can arise due to various other symptoms in the body so pediatric cardiologist will team up with health care providers. For child care, there are pediatric heart surgeons, cardiac anesthesiologists, neonatologists, cardiac pediatric intensivists, pediatric radiologists, as well as pediatric nurses, nutritionists, and speech, occupational, and physical therapists. There are various Tools to diagnose cardiac conditions in children. Based on Physical and cardiac examination. For Physical examination: Vital signs and Cardiac examination will be carried out. For Laboratory examination: Electrocardiography, Chest X-ray, Pulse oximetry, Blood counts, Echocardiography, Magnetic resonance imaging (MRI and MRA), Computed tomography, Exercise testing, Cardiac catheterization are done. Environmental and genetic conditions associated with heart disease in children also play a major role. There are various Unusual forms of congenital heart disease in children, Unique cardiac conditions in newborn infants, cardiac conditions acquired during childhood, Abnormalities of heart rate and conduction in children and Congestive heart failure in infants and children. For preventing follow the treatment and precautions given by pediatric cardiologist and have a healthy lifestyle

3-Treatments for Heart-Disease that are changing lives

A Drug for Heart Failure: The failure of the heart muscle to forcefully pump blood to the body’s tissues is a common disorder called Congestive heart failure. Heart attacks (stroke), high blood pressure, or diseases that weaken the heart muscle are common causes. The severe shortness of breath or fatigue that limits the ability to enjoy a life of the patients. Paradigm-HF is used in the large clinical trial, the new drug LCZ696 was used to treat heart failure, and it was highly effective. It achieved a substantial 20 % reduction in death or repeat hospitalization compared with the best currently available therapies. Currently, 20 % or more of patients hospitalized for heart failure are readmitted within 30 days which represents a significant burden for patients and the healthcare system.LCZ696 will probably be approved, providing a new, promising option for the 5.7 million Americans with heart failure.

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Treatment for High Cholesterol: The PSCK9 inhibitor is second innovative drug therapy. These specify class of drugs has moved from discovery to the clinic more rapidly than any cardiovascular advancement. The single most important risk factor for developing coronary heart disease is an elevated level of cholesterol, LDL-C. The best drugs for reducing cholesterol, statins, have been shown to lower the risk of heart attack or stroke up to 35%. Statins have been available for 25 + years and have been enormously successful at reducing the burden of heart disease. Patients cannot tolerate statins or can’t take large enough dosages to adequately reduce cholesterol levels. LDL-C will be very high due to a genetic cause, and even the most powerful statins cannot reduce it to safe levels. PSCK9 inhibitors reduce bad LDL-C by as much as 50 % to 70 %. These drugs are given by every 2 weeks or once a month given by very small needles. These can be self-injected by the automated injector. This new class of drugs appears to be well tolerated even in patients who cannot take statins due to adverse effects.

Less Invasive Surgery: In 2011, the FDA approved a new procedure to treat heart valve disease without a major surgical operation, known as Trans-catheter aortic valve replacement (TAVR). This device is approved for who need an aortic valve replacement, but who are too high risk for standard open-heart surgery.

Is there any connection between heart and brain?

Your heart and your brain are more intricately connected than you may realize. Brain signals the heart to pump its oxygen-rich blood through the autonomic nervous system, and heart responds by delivering blood to the entire body, including to brain. If the brain does not receive enough oxygen from the heart, you may experience symptoms ranging from fuzzy thinking to a life-threatening stroke. When blood flow to the brain is interrupted or blocked by a blood clot or plaque that has broken away from an artery or valve and is floating in the bloodstream leads to stroke. The lack of oxygen can cause brain cells to die, leading to symptoms of dementia, disabilities, or even death. The major step to the heart is also ways to protect the brain. The steps to prevent from the stroke: Managing your blood pressure is especially important because high blood pressure is the leading cause of stroke. It also may cause tiny lesions in the brain that can slow your thinking and progress to a loss of brain function in the future.

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Steps to Take during Heart Surgery: When your Heart Surgery includes the valve replacement, it is all the more important to consider ways to protect your brain. Valve replacement procedures, such as transcatheter aortic valve implantation (TAVI), can be life-saving interventions. It will correct restricted blood flow caused by a narrowing or obstruction of the heart valve. However, during valve replacement, small particles of debris can break loose and find their way into the blood vessels of the brain.

What is good for the heart is good for the brain. Understanding the unique relationship between the heart and brain, and taking steps to protect both of these vital organs throughout life, is important for lifelong health.

 

Battling myocardial infarction by means of nanoparticle tandems

How can injured cardiac tissue resultant of heart attack be treated through replacement muscle cells? An investigation team has presented an innovative method on mice: Muscle replacement cells, which are to endure the function of the damaged tissue, are loaded by means of magnetic nanoparticles. These nanoparticle-loaded cells are then infused into the injured heart muscle and held in place by a magnet, causing the cells to engraft well onto the existing tissue. By means of the animal model, the researchers show that this leads to a considerable improvement in heart function.

In a heart attack, clots more often than not lead to diligent circulatory issues in parts of the heart muscle, which results in heart muscle cells to die. Attempts have been made for some time to revitalize the injured heart tissue with replacement cells. In spite of this, most of the cells are pushed out of the deflate channel during the infusion due to the pumping action of the beating heart. Therefore, only a few spare cells remain in the heart muscle, which implies that restoration is limited.Heart20192 28-09-2018

An interdisciplinary team tested a pioneering approach on how to ensure that the infused replacement cells continue in the desired spot and engraft onto the heart tissue. The tests were performed on mice that had earlier suffered a heart attack. In order to be able to better follow the cardiac muscle replacement EGFP expressing cells from fetal mouse hearts or mouse stem cells were utilized. These fluorescent muscle cells were loaded with small magnetic nanoparticles and infused through a fine cannula into the injured heart tissue of the mice.

In the magnetic field, the nanoparticle-loaded replacement cells remain in place

In few of the rodents treated this manner, a magnet positioned at a distance of a little millimetre from the surface of the heart guaranteed that a large part of the nanoparticle-loaded replacement cells remained at the desired spot. Devoid of a magnet, about a quarter of the added cells remained in the heart tissue, but with a magnet, about 60 percent of them remained in location, throughout the project. Ten minutes in the influence of the magnetic field was previously sufficient to keep a significant proportion of nanoparticle-loaded muscle cells at the target spot. Even days after the procedure, the injected cells remained in position and slowly attached themselves to the existing tissue.

This is remarkable; exceptionally as the infarct tissue is generally undersupplied due to reduced perfusion. In the influence of the magnet, the substitute muscle cells did not die as frequently, engrafted well again and duplicated more. The analysts investigated the reasons intended for the progressed growth: It was established that these implanted heart muscle cells were filled more densely and could stay alive better credit to the more intensive cell-cell interaction. In addition, the genetic material activity of many endurance functions, such as for cellular respiration, was higher than without a magnet in these replacement cells.

The researchers also illustrated that cardiac function significantly improved in mice that were treated with nanoparticle muscle cells in combination with a magnet. Following two weeks, seven times numerous replacement muscle cells survived, and later than two months, four times as many compared to conventional implantation technology. Known the lifespan of mice of utmost of two years, this is an amazingly lasting effect.

#cardiacarrest #nanoparticle #Stemcell #Heartregeneration

Stem Cell researchers have created cells that line blood vessels

HEART2019 (1)For the first time, researchers have effectively developed the cells that line the veins – called vascular endothelial cells- – from human induced pluripotent stem cells (iPSCs), uncovering new insights about how these cells work. Utilizing a one of a kind approach, the scientists prompted the differentiation of particular cell composes by creating mechanical powers on the surface of the iPSC-determined endothelium imitating the stream of blood. For instance, cells that felt a more grounded “stream” progressed toward becoming artery cells, while those that felt a weaker “stream” moved toward becoming vein cells.

 It was particularly exciting to us to find that these cells are fundamentally reacting to biomechanical prompts. By presenting cells to atheroprone flow, they could coordinate the differentiation of these cells into cells that are available in regions of the circulatory system which are known to influence by infections like atherosclerosis. Researchers are currently taking a shot at demonstrating the arrangement of blood vessel plaques utilizing human iPSC-determined vascular endothelial cells and recognizing potential medications that may avoid plaque development.HEART2019 (2)

They found that the iPS-inferred human endothelial cells show three basic capacities completed by developing endothelium in the body: mounting incendiary reactions, shielding blood from spilling out of the vein, and counteracting blood clumps.

In light of this data, Research work has another exciting ramification – it could possibly lessen, or even dispense with the requirement for heparin use amid kidney dialysis and lung disappointment treatment- – making both especially more secure.

Generally, patients experiencing dialysis are treated with heparin, an intense medication, which keeps the blood from thickening as it’s directed through the dialysis machine. While heparin is very viable in forestalling coagulating, the fact that it significantly diminishes the blood, it can likewise cause loss of blood, interior dying, and meddle with the recuperating procedure.

The iPSC-inferred endothelial cells delightfully work as an anticoagulant surface, Later on, tissue test from a patient can be taken, create iPSCs, and after that cover, an extracorporeal gadget with the patient’s own particular endothelial cells- – so the patient can run home with the gadget without the requirement for normal heparin shots.